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US 5,627,185 AGranted
Acyclovir derivatives as antiviral agents
OwnerGilles Gosselin, Jean-Louis Imbachinventors
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Abstract
Derivatives of Acyclovir are provided having patent antiviral inhibitory activity. Phosphotriester derviatives are preferred which have the structure: ##STR1## where R is alkyl, especially CH.sub.3 or (CH.sub.3).sub.3 C.
Claims14
A phosphotriester compound of the structure:
- (RO).sub.2 --P(.dbd.O)--O--ACV
- where:
- R is --(CH.sub.2).sub.n --S--X wherein:
- X is --C(.dbd.Z)--Y or S--U;
- Z is O or S;
- Y and U are alkyl, aryl or a saccharide which is optionally substituted with OH, SH or NH.sub.2 ;
- n is equal to 1 to 4;
- and
- ACV is an acyclovir moiety.
6 more elements
A compound having the structure:
- ##STR9## where R=CH.sub.3 or (CH.sub.3).sub.3 C.
Dependencies are inferred from the claim text.