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US 5,627,168 AGranted
Pharmaceutical composition for and a method of using a combination of an uricosuric agent and an EAA antagonist
AssigneeWarner-Lambert Company
InventorsChristopher F. Bigge, Graham Johnson, Charles P. Taylor, Jr., Devin F. Welty
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Abstract
The present invention is a pharmaceutical composition having a combination of an uricosuric agent such as probenecid or the like and an excitatory amino acid antagonist useful for treating a disease advantageously affected by treatment with an excitatory amino acid antagonist.
Claims4
A pharmaceutical composition for the treatment of epilepsy, schizophrenia, anxiety or pain which comprises:
- a. an amount of an AMPA excitatory amino acid antagonist effective to treat the disease;
- b. an amount of a uricosuric agent effective to inhibit unidirectional efflux of the AMPA excitatory amino acid antagonist through the blood brain barrier;
- and
- c. a pharmaceutical carrier, provided that the AMPA excitatory amino acid antagonist is not 2,3-dihydro-6-nitro-7-sulfamoylbenzo(F)-quinoxaline.
1 more element
Dependencies are inferred from the claim text.