Treatment of traveller's diarrhea
AssigneeSynsorb Biotech, Inc.
InventorsLouis D. Heerze, Glen D. Armstrong
Life of this patent
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Abstract
This invention relates to treatment of traveller's diarrhea, including diarrhea caused by enterotoxigenic Escherichia coli (ETEC) which treatment uses an oligosaccharide-containing composition. The composition contains an oligosaccharide sequence covalently attached to a pharmaceutically acceptable solid, inert support through a non-peptidyl compatible linker arm. The oligosaccharide-containing composition binds E. coli heat-labile toxin (LT) and/or one or more serotypes of enterotoxigenic E. coli organisms. More specifically, the invention relates to prevention of ETEC from colonizing the intestinal tract and inducing disease. This invention also concerns neutralization and removal of LT associated with traveller's diarrhea.
Claims15
A method to treat traveller's diarrhea mediated by enterotoxigenic E. coli in a subject, which method comprises administering to a subject in need of such treatment an effective amount of a composition comprising an oligosaccharide sequence covalently attached to a pharmaceutically acceptable solid, inert support through a non-peptidyl compatible linker arm, wherein said oligosaccharide sequence binds at least one serotype of enterotoxigenic E. coli, and wherein said composition is capable of being eliminated from the gastrointestinal tract.
A pharmaceutical composition useful in treating traveller's diarrhea and related conditions initiated by enterotoxigenic E. coli, which composition comprises:
- a) an oligosaccharide sequence covalently attached to a pharmaceutically acceptable solid, inert support through a non-peptidyl compatible linker arm, wherein said oligosaccharide sequence binds at least one serotype of enterotoxigenic E. coli;
- and
- b) a pharmaceutically acceptable carrier, wherein said composition is capable of being eliminated from the gastrointestinal tract.
A method to bind and remove enterotoxigenic E. coli from a sample suspected of containing said organism, which method comprises:
- a) contacting said sample with an oligosaccharide sequence covalently attached to a solid, inert support through a non-peptidyl compatible linker arm, wherein said oligosaccharide sequence binds at least one serotype of enterotoxigenic E. coli under conditions wherein said organism is absorbed to said support;
- and
- b) separating the support containing the absorbed organism from the sample.
Dependencies are inferred from the claim text.