US 5,627,161 A · Method for treating tumors with UDPG

Abstract

UDPG shows tumor-specific inhibition of PRPP and this suggests that this action might prove to be useful in combination therapy with inhibitors of purine and pyrimidine nucleotide synthesis in various rescue regimens. High levels of PRPP in tumors were greatly affected by treatment with UDPG.

Claims1

Dependent claims

A method of affecting the intracellular PRPP pool size which comprises exposing normal or tumor cells to pharmacologically active levels of UDPG.

Dependencies are inferred from the claim text.

Facts

Application

08/027,547Filed 8 Mar 1993 · continuation

Priority

20 Dec 1984

Granted

6 May 1997

Term ends

Not estimatedThe source records don’t support an estimate.

Classification2 codes

A61K 31/7072
Having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid: having two oxo groups directly attached to the…
A61K
Medicines and medical preparations

Family

Serial683,873Parent of this continuation-in-part · filed 20 Dec 1984

Serial802,519Parent of this continuation · filed 27 Nov 1985

Serial570,206Parent of this continuation · filed 17 Jul 1990

Serial921,357Parent of this continuation · filed 27 Jul 1992

US 5,627,161 AThis patent

From the US filing history. Foreign family members aren’t listed.

Method for treating tumors with UDPG

Life of this patent

Abstract

Claims1

Method for treating tumors with UDPG

Life of this patent

Abstract

Claims1