Antisense oligonucleotides of human regulatory subunit RI-.sub..alpha. of camp dependent protein kinases for the treatment of cancer
OwnerYoon S. Cho-Chunginventor
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Abstract
Antisense oligonucleotides of human regulatory subunit RI-alpha of cAMP-dependent protein kinases are disclosed along with pharmaceutical compositions containing these oligonucleotides as the active ingredients. These antisense oligonucleotides are useful for inhibiting the growth of cancer.
Claims10
A method for reducing growth of cancer cells susceptible to growth reduction in a mammal comprising administering subcutaneously or parenterally to a mammal in need of such treatment a cancer cell growth-reducing amount of at least one 15- to 30-mer antisense 5' to 3'-oligonucleotide which is complementary to a region in the nucleic acid encoding the first 100 N-terminal amino acids of RI.sub..alpha., which nucleic acid consists of the nucleotide sequence shown as SEQ. ID No:6.
Dependencies are inferred from the claim text.