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US 5,627,157 AGranted
.alpha.-glycosyl hesperidin and its uses
AssigneeKabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo
InventorsHiromi Hijiya, Toshio Miyake
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AssigneeKabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo
InventorsHiromi Hijiya, Toshio Miyake
Estimating the term…
.alpha.-Glycosyl hesperidin, a novel hesperidin derivative wherein equimolar or more D-glucose residues are bound to hesperidin via the .alpha.-bond, is formed by a saccharide-transferring enzyme in a liquid containing hesperidin and .alpha.-glucosyl saccharide. The .alpha.-glycosyl hesperidin is easily recovered from the reaction mixture with a synthetic macroporous resin. .alpha.-Glycosyl hesperidin is superior in water-solubility, substantially tasteless and odorless, free of toxicity, and readily hydrolyzable in vivo into hesperidin and D-glucose to exhibit the physiological activity inherent to hesperidin. Thus, .alpha.-glycosyl hesperidin is favorably usable in vitamin P-enriching agents, foods, beverages, tobaccos, foods, pet foods, pharmaceuticals for susceptive diseases, cosmetics and plastics.
.alpha.-Glucosyl hesperidin which is hydrolyzable by .alpha.-glucosidase (EC 3.2.1.20) into a mixture consisting of hesperidin and D-glucose residue(s).
Food and beverages, which contain an effective amount of an .alpha.-glucosyl hesperidin.
In a pharmaceutical composition comprising a pharmaceutically acceptable carrier and hesperidin as an effective ingredient, the improvement comprising said hesperidin being an .alpha.-glucosyl hesperidin which is hydrolyzable in vivo by .alpha.-glucosidase (EC 3.2.1.20) to exhibit the physiological activities inherent to hesperidin, whereby the water solubility, light resistance and stability of said pharmaceutical composition are improved.
A cosmetic composition which contains as the effective ingredient an effective amount of an .alpha.-glucosyl hesperidin.
Dependencies are inferred from the claim text.