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US 5,627,156 AGranted
Polypeptide agonists for human interleukin-8
AssigneeUniversity of Nebraska Board of Regents
InventorJames E. Talmadge
Life of this patent
Estimating the term…
Abstract
Polypeptides derived from human interleukin-8 (IL-8) which act as therapeutic agents for the therapy of neoplastic (both solid and leukemic) and infectious diseases such as bacterial, fungal, viral and parasitic.
Claims15
A peptide having agonistic activity for alpha chemokines selected from the group consisting of
- i. Glu-Leu-Arg-Cys-Gln-Cys-Ile-Lys-Thr-Tyr-Ser-Lys-Pro-Phe-His-Pro-Lys (SEQ. I.D. No. 1);
- ii. Glu-Leu-Arg-Cys-Gln-Cys-Ile-Lys-Thr-Tyr-Ser-Lys-Pro-Phe (SEQ. I.D. No. 2);
- iii. Glu-Leu-Arg-Cys-Gln-Cys-Leu-Gln-Thr-Leu-Gln-Gly-Ile-His-Pro-Lys (SEQ. I.D. No. 3);
- iv. Glu-Leu-Arg-Cys-Gln-Cys-Leu-Gln-Thr-Leu-Gln-Gly-Ile-His-Leu-Lys (SEQ. I.D. No. 4);
- v. Glu-Leu-Arg-Cys-Gln-Cys-Leu-Gln-Thr-Met-Thr-Gly-Val-His-Leu-Lys (SEQ. I.D. No. 5);
- vi. Glu-Leu-Arg-Cys-Gln-Cys-Leu-Gln-Thr-Leu-Gln-Gly-His-Leu-Lys (SEQ. I.D. No. 6);
- vii. Glu-Leu-Arg-Cys-Met-Cys-Ile-Lys-Thr-Thr-Ser-Gly-Ile-His-Pro-Lys (SEQ. I.D. No. 7);
- viii. Glu-Leu-Arg-Cys-Gln-Cys-Ile-Ser-Thr-His-Ser-Lys-Phe-Ile-His-Pro-Lys (SEQ. I.D. No. 8);
- ix. Glu-Leu-Arg-Cys-Gln-Cys-Leu-Gln-Thr-Val-Ala-Gly-Ile-His-Phe-Lys (SEQ. I.D. No. 10);
- x. Glu-Leu-Arg-Cys-Val-Cys-Leu-Gln-Thr-Thr-Gln-Gly-Val-His-Pro-Lys (SEQ. I.D. NO. 11) and derivatives of said peptides wherein at least one cysteine is substituted by an amino acid of the group consisting of alpha aminobutyric acid, homocysteine and diaminosuberic acid.
7 more elements
Dependencies are inferred from the claim text.