Calcium channel blocking polypeptides from Heteropoda venatoria
AssigneePfizer Inc.
InventorsPaul R. Kelbaugh, Nicholas A. Saccomano, Robert A. Volkmann
Life of this patent
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Abstract
Polypeptides isolated from the venom of the Heteropoda venanoria spider block calcium channels in cells of various organisms and are useful in blocking said calcium channels in cells, per se, in the treatment of calcium channel-mediated diseases and conditions and in the control of invertebrate pests.
Claims36
A substantially pure polypeptide comprising the amino acid sequence, SEQ ID NO:
- 1, or a polypeptide having substantially the same amino acid sequence and substantially the same calcium channel blocking activity as said polypeptide, or a pharmaceutically acceptable salt thereof.
A substantially pure polypeptide comprising the amino acid sequence, SEQ ID NO:
- 2, or a polypeptide having substantially the same amino acid sequence and substantially the same calcium channel blocking activity as said polypeptide, or a pharmaceutically acceptable salt thereof.
A substantially pure polypeptide comprising the amino acid sequence, SEQ ID NO:
- 3, or a polypeptide having substantially the same amino acid sequence and substantially the same calcium channel blocking activity as said polypeptide, or a pharmaceutically acceptable salt thereof.
A substantially pure polypeptide comprising the amino acid sequence, SEQ ID NO:
- 4, or a polypeptide having substantially the same amino acid sequence and substantially the same calcium channel blocking activity as said polypeptide, or a pharmaceutically acceptable salt thereof.
A substantially pure polypeptide comprising the amino acid sequence, SEQ ID NO:
- 5, or a polypeptide having substantially the same amino acid sequence and substantially the same calcium channel blocking activity as said polypeptide, or a pharmaceutically acceptable salt thereof.
A substantially pure polypeptide comprising the amino acid sequence, SEQ ID NO:
- 6, or a polypeptide having substantially the same amino acid sequence and substantially the same calcium channel blocking activity as said polypeptide, or a pharmaceutically acceptable salt thereof.
A substantially pure polypeptide comprising the amino acid sequence, SEQ ID NO:
- 7, or a polypeptide having substantially the same amino acid sequence and substantially the same calcium channel blocking activity as said polypeptide, or a pharmaceutically acceptable salt thereof.
A substantially pure polypeptide comprising the amino acid sequence, SEQ ID NO:
- 8, or a polypeptide having substantially the same amino acid sequence and substantially the same calcium channel blocking activity as said polypeptide, or a pharmaceutically acceptable salt thereof.
A substantially pure polypeptide comprising the amino acid sequence, SEQ ID NO:
- 9, or a polypeptide having substantially the same amino acid sequence and substantially the same calcium channel blocking activity as said polypeptide, or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.