Hybridomas producing antibodies to cardiac hypertrophy factor
AssigneesGenentech, Inc., The Regents of the University of California
InventorsJoffre Baker, Kenneth Chien, Kathleen King, Diane Pennica, William Wood
Life of this patent
Estimating the term…
Abstract
Isolated CHF (also referred to cardiac hypertrophy factor or cardiotrophin-1), isolated DNA encoding CHF, hybridomas and cell lines producing antibodies to CHF, and recombinant or synthetic methods of preparing CHF are disclosed. These CHF molecules are shown to influence hypertrophic activity and neurological activity. Accordingly, these compounds or their antagonists may be used for treatment of heart failure, arrhythmic disorders, inotropic disorders, and neurological disorders.
Claims18
A hybridoma cell line producing an antibody that specifically binds cardiotrophin having amino acid sequence SEQ ID NO.:8.
A hybridoran cell line producing an antibody that specifically binds cardiotrophin-1 having amino acid sequence SEQ ID NO.:
- 3.
A cell line producing an antibody or an antigen-binding fragment thereof that specifically binds cardiotrophin-1 having amino acid sequence SEQ ID NO.:
- 8 or amino acid sequence SEQ ID NO.:
- 3.
An isolated antibody or antigen-binding fragment that specifically binds cardiotruphin-1 having areinn acid sequence SEQ ID NO.:
- 8.
An isolated antibody or antigen-binding fragment that specifically binds cardiotrophin-1 having areinn acid sequence SEQ ID NO.:
- 3.
A kit, comprising a container and, within the container, an antibody or an antigen-binding fragment thereof that specifically binds cardiotrophin-1 having amino acid sequence SEQ ID NO.:
- 8 or amino acid sequence SEQ ID NO.:
- 3.
Dependencies are inferred from the claim text.