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AssigneeBristol-Myers Squibb Company
InventorsAnthony W. Siadak, Mae J. Rosok
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Cell lines have been produced that secrete human monclonal antibodies capable of binding to the lipopolysaccharide molecules of selected Pseudomonas aeruginosa IATS serotypes. Pharmaceutical compositions containing these antibodies, which can be in combination with other monoclonal antibodies, blood plasma fractions and antimicrobial agents, and the prophylactic and therapeutic use of such compositions in the management of infections are included. Prior to filing of this patent application the continuous transformed human cell lines 1C1, 6D6, and 8H7 described herein were deposited in the American Type Culture Collection and given the designations CRL 8941, 9171, and 9258, respectively.
An immortalized cell line which secretes a human monoclonal antibody or binding fragment thereof which specifically binds to accessible lipopolysaccharide determinants of IATS serotypes 4 and 11 and Fisher immunotype 2 of Pseudomonas aeruginosa.
An immortalized cell line which secretes a human monoclonal antibody or binding fragment thereof which specifically binds to accessible lipopolysaccharide determinants of IATS serotypes 6 and 13 and Fisher immunotype of Pseudomonas aeruginosa.
An immortalized cell line which secretes a human monoclonal antibody or binding fragment thereof which specifically binds to accessible lipopolysaccharide determinants of IATS serotypes 2 and 5 and Fisher immunotype 3 of Pseudomonas aeruginosa.
Dependencies are inferred from the claim text.