US 5,626,884 A · Treatment of sickle cell disease

Abstract

A maintenance regimen with controlled intake of particular vitamin, mineral, and micronutrient formulations, drastically reduces the incidence and severity of sickle cell disease crises. The formulations include vitamin A, vitamin B-1, vitamin B-2, vitamin B-6, vitamin B-12, vitamin C, vitamin D, vitamin E, niacinamide, para-aminobenzoic acid (PABA), pantothenic acid, choline bitartrate, inositol, rutin, citrus bioflavonoid complex, betaine hydrochloride, hesperidin complex, folic acid, biotin, calcium, iron, magnesium, zinc, potassium, manganese, iodine, chromium, selenium, and a pharmaceutically acceptable carrier, provided at or just below critical saturation levels, determined for each individual by carefully monitoring tolerance on titration. The daily dose may exceed that necessary as dietary or nutritional supplements, and trigger an increase in the production of viable hemoglobin, and alters the overall blood profile. Platelet concentration is increased up to twice that of seen in normal blood, and the red blood cells produced display increased resistance to sickling. This enhanced biosynthesis is achieved by providing sufficient stores of precursors that stimulate low level manufacture without substantial feedback control by the upper central nervous system.

Claims4

Dependent claims

A method for treating or preventing sickle cell crises in a person having sickle cell disease which comprises administering to said person a cumulative daily dosage of from about 8,250 to 250,000 I.U. vitamin A;

from about 25 to 1000 mg. each of vitamin B-1, vitamin B-2, vitamin B-6, vitamin C, niacinamide, para-aminobenzoic acid, pantothenic acid, choline bitartrate, and inositol;
from about 25 to 1000 mcg. each of vitamin B-12 and biotin;
from about 100 to 4000 I.U. of vitamin D;
from about 100-4000 mcg. of folic acid;
from about 25 to 1000 I.U. of vitamin E;
from about 8.25 to 250 mg. each of rutin, citrus bioflavonoid complex, betaine hydrochloride, and iron;
from about 1.25 to 50 mg. of hesperidin complex, from about 10 to 400 mg. of calcium;
from about 5 to 100 mg. of magnesium;
from about 5 to 100 mg. of zinc;
from about 3.75-150 mg. of potassium;
from about 1.5 to 60 mg. of manganese;
from about 37.5 to 1500 mcg. of iodine;
from about 3.75 to 150 mcg. of chromium;
and from 2.5-100 mcg. of selenium.

11 more elements

Dependencies are inferred from the claim text.

Treatment of sickle cell disease

Life of this patent

Treatment of sickle cell disease

Life of this patent

Abstract

Claims4