Reduction of electrostatic forces between magnesium trisilicate adsorbates
AssigneeWarner-Lambert Company
InventorsFelipe Garay, Stanley Lech, Mark Oehling
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Abstract
A medicament adsorbate containing corn syrup having contained therein from about 10 to about 90% by weight of the adsorbate of a medicament drug a magnesium trisilicate having a surface area of at least 400 m.sup.2 /g and having a structure with multiple interstitial spaces, and having adsorbed therein from about 0.5 to about 30% by weight of the adsorbate of a medicament drug, wherein the medicament drug is an antihistamine. A reduction in the electrostatic forces between adsorbates is experienced due to the particle size of the adsorbate being in the range greater than 40 to about 800 um, most of the adsorbates prepared being a particle size greater than 150 um, which allows for better processing.
Claims24
A medicament adsorbate which comprises an effective amount of a binder to reduce the electrostatic forces of the adsorbate and containing adsorbed therein from about 10% to about 90% by weight of the adsorbate magnesium trisilicate wherein the magnesium trisilicate has a surface area of at least 400 m.sup.2 /g and a structure with multiple interstitial spaces and containing adsorbed therein from about 0.5% to about 30% by weight of the adsorbate of a medicament drug, the medicament adsorbate being of a size characterized by a density in the range from about 700 to about 1000 grams/liter.
A medicament adsorbate which consists essentially of from about 0.5 to about 60% by weight of the adsorbate a binder and magnesium trisilicate adsorbed therein from about 10 to about 90% by weight of the adsorbate wherein the magnesium trisilicate has a surface area of at least 400 m.sup.2 /g and a structure with multiple interstitial spaces and containing adsorbed therein from about 0.5 to about 30% by weight of the adsorbate of diphenhydramine hydrochloride, the adsorbate being of a size in the range greater than 150 to about 600 um.
A process for preparing a medicament adsorbate which comprises dissolving a medicament drug in solvent, admixing magnesium trisilicate wherein the magnesium trisilicate has a surface area of at least 400 m.sup.2 /g and a structure with multiple interstitial spaces and admixing a binder to prepare a mass having a homogenous consistency to enable migration of the medicament drug within the intersistial spaces of the magnesium trisilicate, and recovering the medicament adsorbate product.
Dependencies are inferred from the claim text.