Floating system for oral therapy
AssigneeLTS Lohmann Therapie-Systeme AG
InventorsWalter M uller, Edzard Anders
Life of this patent
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Abstract
The invention relates to a floatable, oral, therapeutic system, in which a lengthening of the gastrointestinal residence time of medicaments and a controlled delivery thereof are achieved by systems, which are specifically lighter than the gastric fluid, float on the latter and can only with difficulty reach the lower-lying pylorus, said system using at least one structural element with cavities or voids, such as foams or hollow bodies.
Claims15
A therapeutic system for the oral administration of a medicament comprising a mixture of particles of the medicament in a therapeutically effective amount and a floatable aid part,
- wherein the floatable aid is a microporous foam material of a polymer selected from the group consisting of polyethylene, polypropylene, polyamide, polystyrene, polyester, polyacrylate, polytetrafluoroethylene, polyvinylchloride, polyvinylidene chloride, copolymers from the monomers on which said polymers are based and polysiloxane,
- wherein the floatable aid comprises a microporous foam material having a pore diameter of in the range of between 0.2 and 100 micrometers,
- wherein the microporous foam material does not contain the medicament within its pores,
- wherein the system delivers the medicament into gastric juices, and
- wherein the system floats in the gastric juices.
A therapeutic system for the oral administration of medicament comprising a medicament-containing part having a therapeutically effective amount of the medicament and a floatable aid part having a cavity-containing character,
- wherein the system delivers the medicament into the gastric juices,
- wherein the medicament is in physical contact with the floatable aid,
- wherein the floatable aid is a microporous foam material of a polymer selected from the group consisting of polyethylene, polypropylene, polyamide, polystyrene, polyester, polyacrylate, polytetrafluoroethylene, polyvinylchloride, polyvinylidene chloride, copolymers from the monomers on which said polymers are based and polysiloxane,
- wherein the floatable aid comprises a microporous foam material having a pore diameter of in the range of between 0.2 and 100 micrometers,
- wherein the microporous foam material does not contain the medicament within its pores, and
- wherein the floatable aid floats in the gastric juices.
Dependencies are inferred from the claim text.