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US 5,626,869 AGranted
Pharmaceutical composition containing a defined lipid system
AssigneePharmacia & Upjohn Company
InventorsH.ang.kan Nyqvist, Monica Einarsson, Christer Mattsson
Life of this patent
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Abstract
The present invention relates to pharmaceutical compostions containing a defined lipid system of at least two lipid components where at least one of the lipid components is amphiphatic and polar and one is nonpolar wherein the pharmaceutically active compound is a heparin or a fragment thereof. In the compositions a water containing solvent also is included in such an amount that discrete lipid particles are present, and said compositions can be adapted to various administration forms such as rectal, oral, buccal, transdermal etc.
Claims15
A pharmaceutical composition comprising:
- a) a well defined lipid system containing:
- i) at least one amphiphatic, polar and bilayer forming phospholipid component in an amount of 5 to 50 w/w of the lipid system;
- and
- ii) a non-polar lipid component comprising a mixture of monoglycerides wherein the fatty acid portion of each of said monoglycerides is from an acid selected from the group consisting of 8:0 caprylic acid and 10:0 capric acid;
- b) a therapeutically effective amount of a heparin present in an amount of 1-200% (w/w) with respect to said lipid system;
- and
- c) water present in amount such that individual lipid particles are formed spontaneously when interacting with excess water.
4 more elements
Dependencies are inferred from the claim text.