Method for regulating metabolism with dopamine beta hydroxylase inhibitors
AssigneesThe Board of Supervisors of Louisana State and Agricultural and Mechanical College, Ergo Science Incorporated
InventorsAnthony H. Cincotta, Albert H. Meier, John M. Wilson
Life of this patent
Estimating the term…
Abstract
Disclosed herein are methods for regulating or ameliorating lipid and glucose metabolism and reducing in a vertebrate animal body fat stores, insulin resistance, hyperinsulinemia, hyperglycemia, hyperlipidemia, elevated blood lipoproteins (such as triglycerides and cholesterol including chylomicrons, VLDL and LDL) and/or increasing in the subject the plasma HDL. The methods comprise administration or timed administration of inhibitors of dopamine beta hydroxylase (DBH).
Claims17
A method for modifying glucose metabolism in a vertebrate animal or human subject in need of such treatment which comprises administering to said subject at a predetermined time of day, an effective amount for inhibiting DBH in said animal or human of a compound having the property of inhibiting DBH.
A method for ameliorating glucose metabolism disorders in a vertebrate animal or human subject in need of such treatment which comprises administering to said subject at a predetermined time of day an effective amount for inhibiting the enzyme dopamine beta hydroxylase in said mammal of a compound having the property of inhibiting the enzyme dopamine beta hydroxylase, said administration being effective to accomplish at least one of the following:
- decrease hyperglycemia;
- decrease glucose intolerance;
- decrease insulin resistance, and decrease hyperinsulinemia;
- and continuing said administration for a sufficient period of time to cause said amelioration to persist after cessation of said administration.
Dependencies are inferred from the claim text.