Method to ameliorate osteolysis and metastasis
AssigneeXenotech LLC
InventorsToshiyuki Yoneda, Gregory R. Mundy
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Abstract
Materials immunoreactive with parathyroid hormone-related protein (PTH-rp) are used in the invention method to prevent and treat metastasis and cancer cell growth in bone as well as osteolysis and symptomatic sequelae thereof. Humanized antibodies are included in the invention for application of the invention method to human subjects.
Claims14
A method of treating growth of metastasized cancer cells on bone which method comprises administering to a subject in need of such treatment an amount of anti-PTH-rp sufficient to treat said growth.
The method of claim wherein said cancer cells are selected from the group consisting of squamous cell carcinoma cells, adenocarcinoma cells, melanoma cells, osteosarcoma cells, and hematologic cancer cells.
A method to preventing metastasis of cancer cells to bone which method comprises administering to a subject in need of such an amount of anti-PTH-rp sufficient to prevent said metastasis.
Dependencies are inferred from the claim text.