Injectable opacifying composition containing liposomes of high encapsulation capacity for X-ray examinations
AssigneeBracco S.p.A.
InventorsMichel Schneider, Herv e Tournier, Bernard Lamy
Life of this patent
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Abstract
Injectable aqueous composition intended for opacifying certain organs with a view to examination by X-rays. This composition is based on liposomes containing, encapsulated thereein, an aqueous solution of an iodinated opacifying agent. The ratio between the weight of iodine encapsulated by the liposomes and the weight of the lipids from which their membrane is formed is not lower than 1.5 mg/mg.
Claims7
A method of diagnostic examination with X-rays which comprises injecting into the circulation of patients to be examined, for the purpose of opacifying organs, an aqueous composition formed of a suspension in a physically tolerable medium of liposome vesicles having a lipidic membrane containing, encapsulated in these vesicles, at least one iodinated organic compound opaque to X-rays in aqueous solution, wherein the vesicles of the liposomes have a mean size which is between 0.15 and 3 .mu.m, and that the ratio of the weight of the iodine encapsulated in the liposomic vesicles to the weight of the lipids of said membrane is from (1.75-6):1.
Dependencies are inferred from the claim text.