Separations by simulated moving bed chromatography operating at low K' values using weakly interating adsorbents as the stationary phase
AssigneeUop LLC
InventorsJames W. Priegnitz, Beth McCulloch
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Abstract
Resolution of a mixture of organic materials by simulated moving bed chromatography using a weakly interacting adsorbent as a stationary phase can be routinely effected with a liquid mobile phase characterized by atypically low values of k' with recoveries of at least 95% and a purity of at least 95%. In particular, values in the range 0.1<k'<1.0 are recommended with a resulting savings in mobile phase consumption, inventory, and recovery.
Claims3
In a process for the separation of at least one material from a mixture of organic materials by simulated moving bed chromatography using a weakly interacting adsorbent as a solid stationary phase, said adsorbent selected from the group consisting of silica, alumina, titania, magnesia, and layered double hydroxides, the improvement comprising effecting said separation using a liquid mobile phase which affords a retention capacity, k', such that 0.1<k'<1.0.
Dependencies are inferred from the claim text.