Multifunction device for the treatment of blood

A multifunction device for extrarenal purification by extracorporeal circulation of blood, comprising a semipermeable separator component, wherein

• a) the separator component is active in adsorption and has at least one of the adsorption capacities below:
• a1:
• adsorption of the TNF-.alpha. greater than or equal to approximately 600 ng;
• a2:
• adsorption of the complement factor D greater than or equal to approximately 30 mg;
• a3:
• adsorption of the interleukin 1-.beta. greater than or equal to approximately 300 ng;
• b) the separator component has a urea clearance greater than or equal to approximately 20 ml/min for rates of blood flow, of dialysis liquid flow and of ultrafiltration equal respectively to approximately 100 ml/min, 33 ml/min and 0 m/min;
• c) the separator component has an ultrafiltration coefficient in the presence of blood greater than approximately 5 ml/(h.mmHg);
• and
• d) the device contains a compartment for circulation of blood having a volume less than or equal to approximately 150 ml;
• said separator component comprising a hollow fiber having
• a) an internal diameter of between approximately 180 and approximately 260 .mu.m;
• b) the composition of a homogeneous and symmetrical polyelectrolytic hydrogel;
• c) a hydraulic permeability Lp greater than approximately 5 ml/h/mmHg/m.sup.2 ;
• d) a membrane resistance to urea less than approximately 200 min/cm, and
• e) the capacity to adsorb at least one of THF-.alpha., complement factor D or interleukin 1-.beta. and a linear adsorption capacity is greater than approximately 125 pg/m for TNF-.alpha., greater than approximately 6 .mu.g/m for factor D or greater than approximately 60 pg/m for interleukin 1-.beta..