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US 5,626,757 AGranted
Macrocyclic antibiotics as separation agents
AssigneeAdvanced Separation Technologies Incorporated
InventorDaniel Armstrong
Life of this patent
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Abstract
Macrocyclic antibiotics having ring structures with at least 10 members act as separation agents in crystallization, precipitation, filtration, electrophoresis and chromatography. The macrocyclic antibiotics include ansamacrolides, macrolides, macrocyclic peptides, polyenes and derivatives thereof. The process has been found to be especially advantageous for separation of optical isomers by electrophoresis and chromatography.
Claims10
A process for sequentially separating enantiomers from a fluid solution containing said enaantiomers comprising the steps of:
- (a) treating a fluid containing said enantiomers with a macrocyclic antibiotic by means of chromatography to cause said enantiomers to sequentially separate one from another, said macrocyclic antiobiotic being a glycopeptide, a glycopeptide derivative, an ansamacrolide or an ansamacrolide derivative, said macrocyclic antibiotic is affixed to a support such that said macrocyclic antibiotic is a stationary phase, said macrocyclic antibiotic interacting with said enantiomers to cause sequential separation by means of more than one of the follfowing mechanisms:
- complexation, charge-charge interaction, hydrogen bonding, inclusion in a hydrophobic pocket, dipole stacking, and steric interaction;
- and
- (b) recovering the sequentially separated enantiomers as individual enantiomers.
1 more element
Dependencies are inferred from the claim text.