Respiratory nose-only device and system for laboratory animals
AssigneeHer Majesty the Queen in right of Canada, as represented by the Minister of Health
InventorsRenaud Vincent, Josee Guenette
Life of this patent
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Abstract
An apparatus for exposing laboratory animals to test substances comprises, generally, at least two supply manifolds for supplying each a gaseous or a vaporous substance, an exhaust manifold for removing an exhalate of said animals and unused portion of said test substance, and a plurality of inhalation chambers. Each chamber is dimensioned to accommodate a nasal part of the animal's head and is in fluid communication with the at least two supply manifolds and with the exhaust manifold. The apparatus is designed to prevent the streams of test substances hitting the animal's nostrils and causing an avoidance reaction.
Claims12
An apparatus for exposing laboratory animals to a test substance, the apparatus comprising:
- at least two separate supply manifolds for supplying each a gaseous or a vaporous substance,
- a plurality of inhalation chambers, each chamber dimensioned to accommodate a nasal part only of the animal's head,
- a first plurality of separate passageways each for conveying said substance from a first of said at least two supply manifolds directly to one of said inhalation chambers,
- a second plurality of separate passageways each for conveying said substance from a second of said two supply manifolds directly to one of said inhalation chambers,
- wherein said substances supplied through said at least two supply manifolds are substantially prevented from mixing with each other before entering said inhalation chambers respectively, and
- an exhaust manifold in fluid communication with said inhalation chambers for removing an exhalate of said animals and unused portion of said test substance.
An apparatus for exposing laboratory animals to a test substance or substances, the apparatus comprising:
- an exhaust manifold,
- at least two separate supply manifolds disposed concentrically relative to said exhaust manifolds,
- a plurality of inhalation chambers disposed peripherally relative to said exhaust manifold and said supply manifolds,
- a plurality of exhaust conduits, each conduit extending substantially radially from said exhaust manifold to one of said inhalation chambers, for conveying exhalate from said inhalation chambers to said exhaust manifold,
- a first plurality of separate conduits each for conveying said substance from a first of said at least two supply manifolds directly to one of said inhalation chambers,
- a second plurality of separate conduits each for conveying said substance from a second of said two supply manifolds directly to one of said inhalation chambers,
- wherein said substances supplied through said at least two supply manifolds are substantially prevented from mixing with each other before entering said inhalation chambers respectively, each of said chambers having a cross-sectional size significantly exceeding a cross-sectional size of each of said supply conduits, and
- means for directing, in operation, a flow of said substances supplied into said inhalation chambers, away from the nostrils of said animal when placed in said apparatus.
Dependencies are inferred from the claim text.