Chemical compounds as inhibitors of amyloid beta protein production
AssigneeEli Lilly and Company
InventorsJon K. Reel, Richard L. Simon, Celia A. Whitesitt
Life of this patent
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Abstract
A compound of the formula I in which ##STR1## Z is O or S; R.sup.11 is a halogen atom; R.sup.12 is a halogen atom or a trifluoromethyl group; and X is S, SO, SO.sub.2, O or NH; R.sup.4 is naphthyl, quinolinyl, benzimidazolyl, pyridyl, pyradazinyl, benzoxazolyl or benzothiazolyl, unsubstituted or substituted by one or two substituents selected from a halogen atom, (1-4C)alkyl, (1-4C)alkoxy, nitro, (1-4C)alkoxycarbonyl, halo(1-4C)alkyl, and phenyl; or a pharmaceutically acceptable salt thereof. The compounds are useful as inhibitors of amyloid beta-protein production.
Claims12
A compound of the formula ##STR5## in which Z is O or S;
- R.sup.11 is a halogen atom;
- R.sup.12 is a halogen atom or a trifluoromethyl group;
- X is S, SO, SO.sub.2, O or NH;
- and
- R.sup.4 is naphthyl, quinolinyl, benzimidazolyl, pyridyl, pyridazinyl, benzoxazolyl or benzothiazolyl, unsubstituted or substituted by one or two substituents selected from a halogen atom, (1-4C)alkyl, (1-4C)alkoxy, nitro, (1-4C)alkoxycarbonyl, halo(1-4C)alkyl, and phenyl;
- with the proviso that when R.sup.4 is pyridyl or pyridazinyl X must be S, SO, SO.sub.2 or NH;
- or a pharmaceutically acceptable salt thereof.
A pharmaceutical composition which comprises a compound of the formula ##STR6## in which Z is O or S;
- R.sup.11 is a halogen atom;
- R.sup.12 is a halogen atom or a trifluoromethyl group;
- X is S, SO, SO.sub.2, O or NH;
- and
- R.sup.4 is naphthyl, quinolinyl, benzimidazolyl, pyridyl, pyridazinyl, benzoxazolyl or benzothiazolyl, unsubstituted or substituted by one or two substituents selected from a halogen atom, (1-4C)alkyl, (1-4C)alkoxy, nitro, 1-4C)alkoxycarbonyl, halo(1-4C)alkyl, and phenyl;
- or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable diluent or carrier.
Dependencies are inferred from the claim text.