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US 5,624,898 AGranted
Method for administering neurologic agents to the brain
AssigneeRamsey Foundation
InventorWilliam H. Frey, II
Life of this patent
Estimating the term…
Abstract
Disclosed is a method for transporting neurologic therapeutic agents to the brain by means of the olfactory neural pathway and a pharmaceutical composition useful in the treatment of brain disorders.
Claims10
A method for delivering a neurologic therapeutic agent to the brain of a mammal, comprising:
- applying an effective amount of the neurologic therapeutic agent directly to the olfactory epithelium of the nasal cavity of the mammal, wherein the neurologic agent is basic fibroblast growth factor and combined with a pharmaceutically-acceptable carrier, an effective amount of lipophilic micelles, or a combination thereof;
- the neurologic agent being unable to be delivered to the brain from the circulatory system of the mammal by crossing the blood-brain barrier of the mammal;
- wherein the neurologic agent is absorbed through the olfactory epithelium of the nasal mucosa into olfactory neurons and an effective amount of the agent is transported into the brain of the mammal by means of the olfactory neural pathway to provide a protective effect on brain cells against stroke.
A method for delivering a neurologic therapeutic agent to the brain of a mammal, comprising:
- applying an effective amount of the neurologic therapeutic agent directly to the olfactory epithelium of the nasal cavity of the mammal, wherein the neurologic agent is nerve growth factor and combined with a pharmaceutically-acceptable carrier, an effective amount of lipophilic micelles, or a combination thereof;
- the neurologic agent being unable to be delivered to the brain from the circulatory system of the mammal by crossing the blood-brain barrier of the mammal;
- wherein the neurologic agent is absorbed through the olfactory epithelium of the nasal mucosa into olfactory neurons and an effective amount of the agent is transported into the brain of the mammal by means of the olfactory neural pathway to inhibit degeneration of nerve cells in the brain.
Dependencies are inferred from the claim text.