Pharmaceutical compositions and methods of treatment of the cornea following laser irradiation
AssigneeAlcon Laboratories, Inc.
InventorJohn M. Yanni
Life of this patent
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Abstract
Methods for treating the cornea following laser irradiation are disclosed. The methods include administration of compositions of wound healing modulators and pain mediators to the eye. Compositions for use in treating the cornea are also disclosed.
Claims15
A method for treating the cornea for haze or pain following laser irradiation and resulting photoablation of corneal tissue comprising, applying to the affected eye, a therapeutically effective amount of a composition comprising a wound healing modulator and a pain mediator wherein the wound healing modulator is selected from the group consisting of:
- steroids, growth factors, basement membrane components, anti-oxidants, regulators of collagen structure, aldose reductase inhibitors, nonsteroidal antiiflammatories, immunomodulators, antiallergics, fatty acid derivatives of arachidonic acid and antimicrobials and the pain mediator is a neurokinin-1 antagonist.
A topical ophthalmic composition for treating the cornea for haze or pain following photoablation of the corneal during ophthalmic surgery, comprising, a therapeutically effective amount of a wound healing modulator, a therapeutically effective amount of a pain mediator and an ophthalmically acceptable carrier therefore, wherein the wound healing modulator is selected from the group consisting of:
- steroids, growth factors, basement membrane components, anti-oxidants, regulators of collagen structure, aldose reductase inhibitors, nonsteroidal antiiflammatories, immunomodulators, antiallergics, fatty acid derivatives of arachidonic acid and antimicrobials and the pain mediator is a neurokinin-1 antagonist.
A method for treating the cornea following laser irradiation and resulting photoablation of corneal tissue comprising, applying to the affected eye, a therapeutically effective amount of a neurokinin-1 antagonist.
Dependencies are inferred from the claim text.