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US 5,624,669 AGranted
Method of hemostatic sealing of blood vessels and internal organs
AssigneeTri-Point Medical L.P.
InventorsJeffrey C. Leung, Jeffrey G. Clark
Life of this patent
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Abstract
Hemostatic procedures for sealing punctures and incisions in blood vessels and internal organs involve applying to a puncture or incision surface a biocompatible adhesive composition.
Claims20
A method of hemostatic sealing of puncture or incision surfaces in an internal organ or blood vessel, which comprises,
- (a) applying to at least a portion of said puncture or incision surfaces an adhesive composition comprising:
- (i) at least one monomer of the formula:
- CHR.dbd.CXY (I)
- wherein X and Y are each strong electron withdrawing groups, and R is H or, provided that X and Y are both cyano groups, a C.sub.1 -C.sub.4 alkyl group;
- and
- (ii) an effective amount of at least one biocompatible agent effective to reduce active formaldehyde concentration levels;
- and
- (b) polymerizing said adhesive composition in situ.
5 more elements
A method of hemostatic sealing of puncture or incision surfaces in an internal organ or blood vessel in vivo, which comprises:
- applying to at least a portion of said puncture or incision surfaces a sealing composition comprising:
- (i) at least one monomer which forms a polymer whose in vivo biodegradation produces formaldehyde;
- and
- (ii) an effective amount of at least one biocompatible agent effective to -reduce active formaldehyde concentration levels;
- wherein the at least one monomer has the formula:
- CHR.dbd.CXY
- wherein R is H, C.sub.1 -C.sub.4 alkyl group, or --CH.dbd.CH.sub.2 group, and X and Y are both strong electron withdrawing groups.
4 more elements
Dependencies are inferred from the claim text.