Method of treating brain tumors expressing tenascin

A method of treating a solid brain tumor which expresses tenascin, in a human subject in need of such treatment, comprising:

• removing a solid brain tumor expressing tenascin from an afflicted human subject;
• then
• forming an enclosed resection cavity at the location from which said solid brain tumor was removed, and then
• administering to said subject an antibody that binds to tenascin in a therapeutically effective amount,
• wherein said administering step is carried out by depositing said antibody in said resection cavity,
• wherein said antibody is coupled to a radioisotope, and
• wherein said antibody is selected from the group consisting of monoclonal antibody 81C6 and antibodies that bind to the epitope bound by monoclonal antibody 81C6.

A method of treating a solid astrocytic tumor which expresses tenascin in the brain of a human subject in need of such treatment, comprising:

• removing a solid astrocytic tumor expressing tenascin from the brain of an afflicted human subject;
• then
• forming an enclosed resection cavity in the brain of said subject at the location from which said solid tumor was removed;
• and then
• administering to said subject antibody 81C6 coupled to .sup.131 I in a therapeutically effective amount,
• wherein said administering step is carried out by depositing said antibody in said resection cavity.