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US 5,623,070 AGranted
Heteroatomic oligonucleoside linkages
AssigneeIsis Pharmaceuticals, Inc.
InventorsPhillip D. Cook, Yogesh S. Sanghvi
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Abstract
Oligonucleotide-mimicking macromolecules that have improved nuclease resistance are provided. Replacement of the normal phosphorodiester inter-sugar linkages found in natural oligonucleotides with three or four atom linking groups provide unique oligonucleotide-mimicking macromolecules that are useful in regulating RNA expression and in therapeutics. Methods of synthesis and use also are disclosed.
Claims8
A nucleoside of the structure:
- ##STR4## wherein Y.sub.1 is CH.sub.2 ;
- Y.sub.2 is aminooxy, alkylamino having 1 carbon atom, or alkenyl having 2 carbon atoms;
- Z is H, OH, O--R'", amino, methyleneamino or phthalimido;
- R'" is a hydroxyl blocking group;
- X is H or OH;
- Q is O;
- and
- Bx is a heterocyclic base moiety.
5 more elements
Dependencies are inferred from the claim text.