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US 5,622,699 AGranted
Method of identifying molecules that home to a selected organ in vivo
AssigneeLa Jolla Cancer Research Foundation
InventorsErkki Ruoslahti, Renata Pasqualini
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Abstract
The present invention provides methods for in vivo panning of a library to identify molecules that specifically home to a selected organ.
Claims5
A method of obtaining a molecule selected from the group consisting of a peptide, a polypeptide, a protein, and a fragment of a protein that homes to a selected organ or tissue, comprising the steps of:
- a. administering to a subject a phage display library expressing diverse molecules;
- b. collecting a sample of the selected organ or tissue;
- and
- c. identifying a molecule that homes to said selected organ or tissue, wherein said molecule is expressed on a phage present in said sample.
1 more element
Dependencies are inferred from the claim text.