1,3-oxathiolane nucleoside analogues and methods for using same
AssigneeBioChem Pharma Inc.
InventorGervais Dionne
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Abstract
The invention relates to 1,3-oxathiolane nucleoside analogues and their use in the treatment of viral infections. More specifically, this invention relates to (-)-4-amino-5-fluoro-1-(2-hydroxymethyl-1,3-oxathiolan-5-yl)-(1H)-pyrimidi n-2-one and pharmaceutically acceptable derivatives and pharmaceutical formulations thereof.
Claims4
A method for treating a viral infection in a mammal comprising administering to a mammal in need thereof, an antiviral effective amount of (-)-Cis-4-amino-5-fluoro-1-(2-hydroxymethyl-1,3-oxathiolan-5yl)-(1H)-py rimidin-2-one or a pharmaceutically acceptable salt, ester or salt of an ester thereof.
A method for treating a viral infection in a mammal comprising administering to a mammal in need thereof, an antiviral effective amount of a mixture of (-)-Cis-4-amino-5-fluoro-1-(2-hydroxymethyl-1,3-oxathiolan-5-yl-(1H)-pyrim idin-2-one or a pharmaceutically acceptable salt, ester or salt of an ester thereof, and (+)-Cis-4-amino-5-fluoro-1-(2-hydroxymethyl-1,3-oxathiolan-5-yl)-(1H)-pyri midin-2-one or a pharmaceutically acceptable salt, ester or salt of an ester thereof, wherein the (+)-enantiomer is present in an amount of no more than 5% w/w.
Dependencies are inferred from the claim text.