Stereoselective microbial reduction of 5-fluorophenyl-5-oxo-pentanoic acid and a phenyloxazolidinone condensation product thereof
AssigneeSchering Corporation
InventorsMichael J. Homann, Edward Previte
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Abstract
A stereoselective reduction of compound II to compound of formula I ##STR1## which comprises adding ketone substrate II to a culture broth of the Zygosaccharomyces bailii ATCC 38924, incubating the resulting mixture, and isolating a hydroxy compound of formula I, is described. The resulting compound of formula I is useful as an intermediate in the preparation of 1-(4-fluorophenyl)-3(R)-[3(S)-hydroxy-3-(4-fluorophenyl)propyl]-4(S)-(4-hy droxyphenyl)-2-azetidinone which is a serum cholesterol lowering agent. Also described is a stereoselective reduction of a compound of formula IV to compound of formula III ##STR2## using Schizosaccharomyces octosporus ATCC 2479.
Claims2
A stereoselective reduction of a compound of formula II to compound of formula I ##STR6## which comprises adding a compound of formula II to a culture broth of Zygosaccharomyces bailii ATCC 38924, incubating the resulting mixture, and isolating a hydroxy compound of formula I.
A stereoselective reduction of a compound of formula IV to compound of formula III ##STR7## which comprises adding a compound of formula IV to a culture broth of Schizosaccharomyces octosporus ATCC 2479, incubating the resulting mixture, and isolating a hydroxy compound of formula III.
Dependencies are inferred from the claim text.