Chimeric papillomavirus-like particles
AssigneeThe United States of America as represented by the Department of Health and Human Services
InventorsDouglas R. Lowy, John T. Schiller, Heather Greenstone
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Abstract
The present invention provides a papillomavirus-like particle, characterized as having conformational epitopes, comprising a papillomavirus L1 product and a papillomavirus L2 fusion product; and related synthetic DNA molecules, host cells, methods and vaccines.
Claims24
A papillomavirus-like particle characterized as having conformational epitopes, comprising a papillomavirus L1 product and a papillomavirus L2 fusion product.
A synthetic DNA molecule characterized as encoding a papillomavirus L1 product and papillomavirus L2 fusion product, wherein said molecule is capable of directing expression in a transformed cell of papillomavirus-like particles characterized as having conformational epitopes, wherein said particles comprise said papillomavirus L1 product and papillomavirus L2 fusion product.
A host cell transformed with one or more DNA molecules which together encode a papillomavirus L1 product and a papillomavirus L2 fusion product, wherein said molecule(s) direct(s) expression of papillomavirus-like particles characterized as having conformational epitopes, wherein said particles comprise said papillomavirus L1 product and papillomavirus L2 fusion product.
A composition comprising a first synthetic DNA molecule characterized as encoding a papillomavirus L1 product and a second synthetic DNA molecule characterized as encoding a papillomavirus L2 fusion product, wherein said molecules are capable of directing expression in a transformed cell of papillomavirus-like particles characterized as having conformational epitopes, wherein said particles comprise said papillomavirus L1 product and papillomavirus L2 fusion product.
Dependencies are inferred from the claim text.