.alpha.-glycosyl-L-ascorbic acid, and its preparation and uses
AssigneeKabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo
InventorsItaru Yamamoto, Norio Muto, Toshio Miyake
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Abstract
.alpha.-Glycosyl-L-ascorbic acid exhibiting no direct reducing activity is formed in a solution containing L-ascorbic acid and an .alpha.-glucosyl saccharide when subjected to the action of a saccharide-transferring enzyme. .alpha.-Glycosyl-L-ascorbic acid is superiorly stable, and readily hydrolyzable in vivo to exhibit the activities inherent to L-ascorbic acid. Thus, .alpha.-glycosyl-L-ascorbic acid is favorably useful as a stabilizer, quality-improving agent, antioxidant, physiologically active agent and uv-absorbent in food pharmaceutical and cosmetic industries.
Claims5
In a pharmaceutical composition containing a pharmaceutically-acceptable carrier and L-ascorbic acid as an effective ingredient for viral diseases, bacterial diseases, traumatic diseases, immunopathies, allergy, diabetes, cataract and malignant tumors, the improvement wherein
- said L-ascorbic acid is present in a form of an .alpha.-glycosyl-L-ascorbic acid which exhibits no direct reducing activity and has the chemical structure shown by the following formula:
- ##STR5## wherein n is an integer from 0 to 6, said composition containing at least 0.001 w/w% of said .alpha.-glycosyl-L-ascorbic acid.
In a pharmaceutical composition containing L-ascorbic acid and a pharmaceutically acceptable excepient or carrier, the improvement wherein said L-ascorbic acid is in the form of .alpha.-glycosyl-L-ascorbic acid of the formula ##STR7## wherein n is an integer from 0 to 6.
A pharmaceutical composition for the administration to humans in need of vitamin C comprising at least 0.001 w/w% of .alpha.-glycosyl-L-ascorbic acid of the formula ##STR8## wherein n is an integer of from 0 to 6, and a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.