Glutathione N-hydroxycarbamoyl thioesters and method of inhibiting neoplastic growth
AssigneeUniversity of Maryland Baltimore Campus
InventorsDonald J. Creighton, Diana S. Hamilton
Life of this patent
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Abstract
A compound of the formula ##STR1## with R being hydrogen, alkyl, cycloalkyl or aryl, which may be substituted with halogen or alkyl, and R' and R.sup.a being hydroxyl, or --O-alkyl, pharmaceutically acceptable salts thereof; or mixtures thereof. An anti-neoplastic composition comprises the compound described above and a pharmaceutically acceptable carrier. In vitro and in vivo methods of preventing or inhibiting the growth and proliferation of neoplastic cells and/or tumors comprise contacting the cells with or administering to a subject an anti-growth and proliferation effective amount of the compound described above.
Claims25
A compound of the formula ##STR9## wherein R is hydrogen, (C.sub.1 -C.sub.18)alkyl, (C.sub.6 -C.sub.20)aryl, or (C.sub.6 -C.sub.20)aryl substituted with halogen or (C.sub.1 -C.sub.18)alkyl;
- R' is hydroxyl, or --O(C.sub.1 -C.sub.18)alkyl;
- and
- R.sup.a is an --O(C.sub.1 -C.sub.18)alkyl, pharmaceutically acceptable salts thereof, or mixtures thereof.
A compound of the formula ##STR10## wherein R is hydrogen, (C.sub.1 -C.sub.18)alkyl, (C.sub.6 -C.sub.20)aryl, or (C.sub.6 -C.sub.20)aryl substituted with halogen or (C.sub.1 -C.sub.18)alkyl;
- R' is hydroxyl or --O(C.sub.1 -C.sub.18)alkyl;
- and
- R.sup.a is hydroxyl, pharmaceutically acceptable salts thereof, or mixtures thereof.
Dependencies are inferred from the claim text.