Angiographic vascular occlusion agents and a method for hemostatic occlusion
AssigneeThe Regents of the University of California
InventorKent C. Cochrum
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Abstract
Angiographic vascular occlusion agents comprising a biopolymer alone or in combination with platelet-rich plasma. A liquid biopolymer gels in situ in contact with divalent cations. Biopolymer agent achieves permanent occlusion, biopolymer combined with the platelet-rich plasma achieves temporary or semi-permanent occlusion. The plasma is obtained from the patient's own blood to avoid undesirable immunogenic reactions. The occlusion agents have strong occlusive properties when injected into a bleeding vessel.
Claims29
An angiographic vascular occlusion agent injected in situ into a bleeding vessel or a site of injury comprising a biocompatible polymer selected from the group consisting of chitin, and chitosan in a mixture With alginate or with poly-L-amino acid, said polymer being able to gel in the presence of an endogenously present or exogenously added divalent cation.
An angiographic vascular occlusion agent injected in situ into a bleeding vessel or a site of injury, said agent comprising platelet-rich plasma wherein the plasma is concentrated from about 5 to about 10 times, and a biocompatible polymer selected from the group consisting of chitosan, chitin, and chitosan in a mixture with alginate, or with a poly-L-amino acid.
The method of forming an angiographic vascular occlusion comprising administering in situ to a bleeding vessel or a site of injury an aqueous solution of a biocompatible polymer selected from the group consisting of alginate, chitosan, poly-L-amino acid and a mixture thereof, said polymer being able to gel in situ in the presence of an endogenously present or exogenously added divalent cation.
Dependencies are inferred from the claim text.