Compositions for topical delivery of drugs comprising a mixture of high and low HLB surfactants and alkoxylated ether
AssigneeThe Procter & Gamble Company
InventorsRoberta C. Bloom, George E. Deckner
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Abstract
The present invention relates to pharmaceutical compositions for topical application comprising a safe and effective amount of a pharmaceutical active, from about 0.1% to about 10.0% of a high molecular weight cationic polymer, from about 0.05% to about 5% of a high HLB non-ionic surfactant, and from about 0.1% to about 25% of an alkoxylated ether. In further embodiments, these compositions also comprise from about 0.01% to about 5% of a low HLB non-ionic surfactant.
Claims45
A topical pharmaceutical composition having enhanced penetration through the skin, comprising:
- (a) a safe and effective amount of a pharmaceutical active;
- (b) from about 0.1% to about 10.0% of a high molecular weight crosslinked cationic polymer of the formula:
- (A).sub.l (B).sub.m (C).sub.n wherein (A) is a dialkylaminoalkyl acrylate monomer or its quaternary ammonium or acid addition salt, (B) is a dialkylaminoalkyl methacrylate monomer or its quaternary ammonium or acid addition salt, (C) is acrylamide, 1 is an integer of 0 or greater, m is an integer of 1 or greater, and n is an integer of 0 or greater, wherein said polymer contains a crosslinking agent;
- (c) from about 0.05% to about 5% of a high HLB non-ionic surfactant;
- (d) from about 0.1% to about 25% of an alkoxylated ether of the formula:
- ##STR3## wherein R is straight or branched chain C.sub.1 to C.sub.18, and X is methyl or ethyl, and wherein n has an average value of from about 5 to about 20;
- and
- (e) a balance of a pharmaceutically acceptable vehicle comprising a major amount of water.
A topical pharmaceutical composition having enhanced penetration through the skin comprising:
- (a) a safe and effective amount of a pharmaceutical active;
- (b) from about 0.1% to about 10.0% of a high molecular weight crosslinked cationic polymer of the formula:
- (A).sub.l (B).sub.m (C).sub.n, wherein (A) is a dialkylaminoalkyl acrylate monomer or its quaternary ammonium or acid addition salt, (B) is a dialkylaminoalkyl methacrylate monomer or its quaternary ammonium or acid addition salt, (C) is acrylamide, l is an integer of 0 or greater, m is an integer of 1 or greater, and n is an integer of 0 or greater, wherein said polymer contains a crosslinking agent;
- (c) from about 0.05% to about 5% of a high HLB non-ionic surfactant;
- (d) from about 0.01% to about 5% of a low HLB non-ionic surfactant;
- (e) from about 0.1% to about 25% of an alkoxylated ether of the formula:
- ##STR4## wherein R is straight or branched chain C.sub.1 to C.sub.18, and X is methyl or ethyl, and wherein n has an average value of from about 5 to about 20;
- and
- (f) a balance:
- of a pharmaceutically acceptable vehicle comprising a major amount of water.
Dependencies are inferred from the claim text.