Heterocycle-containing carbonic acid derivatives

A compound represented by the following formula (I) or a physiologically acceptable salt thereof:

• ##STR211## wherein the ring D represents a group represented by the following formula:
• ##STR212## where R.sup.1 and R.sup.2 are the same or different and each represents a hydrogen atom, a C.sub.1-6 alkyl group, a C.sub.1-4 alkoxy group, a cycloalkyloxy group, a cycloalkyloxy group substituted with a cyclopropyloxy group, a cyclobutyloxy group, a cyclopentyloxy group, a cyclohexyloxy group or a cycloheptloxy group, a halogen atom, an aryl group, an aryl group substituted with a lower alkyl group, a halogen atom or a lower alkoxy group, an aryloxy group, an aryloxy group substituted with a lower alkyl group, a halogen atom or a lower alkoxy group or a heteroaryl group, or alternatively R.sup.1 and R.sup.2 together form a 5- to 7-membered cycloalkyl ring which is substituted with one or more C.sub.1-6 alkyl groups or a 5- to 7-membered saturated heterocycle containing as the hetero atom S, O, SO, SO.sub.2 or NR.sup.3 where R.sup.3 represents a hydrogen atom or a lower alkyl group, wherein the heterocycle may be substituted with one or more C.sub.1-6 alkyl groups;
• and R.sup.a and R.sup.b are the same or different and each represents a hydrogen atom, a C.sub.1-6 alkyl group or a C.sub.1-4 alkoxy group;
• A represents O, S, SO.sub.2, NR.sup.3 where R.sup.3 is as described above, or CR.sup.4 R.sup.5 where R.sup.4 and R.sup.5 are the same or different and each represents a hydrogen atom or a C.sub.1-6 alkyl group;
• E represents (CH.sub.2).sub.n wherein n is 0, 1 or 2, CHCH.sub.3 or C(CH.sub.3).sub.2 ;
• the symbol ---- represents a single or double bond;
• and
• the ring B represents a group represented by one of the following formulae:
• ##STR213## where R.sup.6 represents a hydrogen atom, a C.sub.1-6 alkyl group, an alkenylalkyl group, an alkynylalkyl group, a bridged cyclic hydrocarbon group, a cycloalkyl group, a cycloalkylalkyl group, a C.sub.1-6 alkoxyalkyl group, an aryl group, a heteroaryl group, an arylalkyl group or a heteroarylalkyl group;
• R.sup.7 represents a group represented by the following formula:
• ##STR214## where the ring G represents a phenylene group or a 5- or 6-membered heterocyclic group having one or two hetero atoms;
• and R.sup.8 represents a hydrogen atom, a hydroxyl group, a C.sub.1-4 alkoxy group, a morpholylalkyloxy group or a group represented by the formula:
• --NR.sup.9 R.sup.10 where R.sup.9 and R.sup.10 are the same or different and each represents a hydrogen atom, a hydroxyl group, a C.sub.1-6 alkyl group, a C.sub.1-4 alkoxy group, a hydroxyalkyl group, an aryl group or a hetroaryl group, or alternatively R.sup.9 and R.sup.10 may form a ring, which may contain a nitrogen atom, an oxygen atom or a sulfur atom, together with the nitrogen atom to which R.sup.9 and R.sup.10 are bonded, R.sup.a is as defined above and R.sup.11 represents a group represented by the formula:
• --COR.sup.8 where R.sup.8 is as defined above.