Retroviral protease inhibitors

Compound represented by the formula:

• ##STR175## or a pharmaceutically acceptable salt thereof, wherein:
• t is either 0 or 1;
• R.sup.1 represents hydrogen, --CH.sub.2 SO.sub.2 NH.sub.2, --CO.sub.2 CH.sub.3, --CONHCH.sub.3, --CON(CH.sub.3).sub.2, --CH.sub.2 C(O)NHCH.sub.3, --CH.sub.2 C(O)N(CH.sub.3).sub.2, --CONH.sub.2, --C(CH.sub.3).sub.2 (SCH.sub.3), --C(CH.sub.3).sub.2 (S[O]CH.sub.3), --C(CH.sub.3).sub.2 (S[O]CH.sub.3), alkyl, haloalkyl, alkenyl, alkynyl and cycloalkyl radicals and amino acid side chains selected from asparagine, S-methyl cysteine and the corresponding sulfoxide and sulfone derivatives thereof, glycine, leucine, isoleucine, allo-isoleucine, tert-leucine, phenylalanine, ornithine, alanine, histidine, norleucine, glutamine, valine, threonine, serine, aspartic acid, beta-cyano alanine, and allothreonine side chains;
• R.sup.2 represents alkyl, aryl, cycloalkyl, cycloalkylalkyl and aralkyl radicals optionally substituted with a group selected from --OR.sup.9, --SR.sup.9, and halogen radicals, wherein R.sup.9 represents hydrogen and alkyl radicals;
• R.sup.3 represents alkyl, alkenyl, alkynyl, hydroxyalkyl, alkoxyalkyl, cycloalkyl, cycloalkylalkyl, heterocycloalkyl, heteroaryl, heterocycloalkylalkyl, aryl, aralkyl, heteroaralkyl, aminoalkyl and mono- and disubstituted aminoalkyl radicals, wherein said substituents are selected from alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroaralkyl, heterocycloalkyl, and heterocycloalkylalkyl radicals, or in the case of a disubstituted aminoalkyl radical, said substituents along with the nitrogen atom to which they are attached, form a heterocycloalkyl or a heteroaryl radical;
• R.sup.4 and R.sup.5, independently represent hydrogen and radicals as defined by R.sup.3, or R.sup.4 and R.sup.5, together with the nitrogen atom to which they are bonded represent heterocycloalkyl and heteroaryl radicals;
• R.sup.30, R.sup.31 and R.sup.32 represent radicals as defined for R.sup.1, or one of R.sup.1 and R.sup.30 together with one of R.sup.31 and R.sup.32 and the carbon atoms to which they are attached form a cycloalkyl radical;
• R.sup.33 and R.sup.34 independently represent hydrogen and radicals as defined for R.sup.3, or R.sup.33 and R.sup.34 together with X' represent cycloalkyl, aryl, heterocyclyl and heteroaryl radicals, provided that when X' is O, R.sup.34 is absent;
• X' represents N, O or C(R.sup.17) wherein R.sup.17 represents hydrogen and alkyl radicals;
• and
• Y, Y' and Y" independently represent O and S.