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AssigneeBoehringer Ingelheim GmbH
InventorsRolf Banholzer, Rudolf Bauer, Richard Reichl
Estimating the term…
Compounds of the formula ##STR1## of which, in exemplary compounds, the thienyl group is attached via the 2-position and: (a) A is 3.alpha.-(6.beta., 7.beta.-epoxy)-tropanyl methobromide and R.sub.1 is 2-thienyl; (b) A is 3.alpha.-(6, 7dehydro)-tropanyl methobromide and R.sub.1 is 2-thienyl; (c) A is 3.beta.-tropanyl methobromide and R.sub.1 is 2-thienyl; and, (d) A is 3.alpha.-(N-isopropyl)-nortropanyl methobromide and R.sub.1 is cyclopentyl. These are anticholinergics. Administered by inhalation, they are useful for the treatment of chronic obstructive bronchitis or slight to moderately severe asthma. Administered by the intravenous or oral routes, they are useful for the treatment of vagally induced sinus bradycardia.
A compound of the formula ##STR26## wherein Q is a group of the formula --CH.sub.2 --CH.sub.2 --, --CH.dbd.CH-- or ##STR27## R and R' are each independently C.sub.1 -C.sub.4 -alkyl;
A compound of the formula ##STR29## wherein X.sup.- is a physiologically acceptable anion.
A compound of the formula ##STR30## wherein X.sup.- is a physiologically acceptable onion.
A compound of the formula ##STR31##
A compound of the formula ##STR32## wherein R.sub.1 is 2-thienyl and A is 3.alpha.-(6,7-dehydro)-tropanyl methobronide.
A compound of the formula ##STR33## wherein R.sub.1 is 2-thienyl and A is 3.beta.-tropanyl methobromide.
A compound of the formula ##STR34## wherein R.sub.1 is cyclopentyl and A is 3.alpha.-(N-isopropyl)-nortropanyl methobromide.
Dependencies are inferred from the claim text.