Electrospraying method for mass spectrometric analysis
AssigneeBruker-Franzen Analytik GmbH
InventorsJochen Franzen, Matthias Mann, Matthias Wilm
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Abstract
A method is provided for analyzing analyte ions in a liquid using a spectrometer incorporating an ion trap, using a capillary nozzle adjacent an inlet aperture for the ion trap. The liquid is electrosprayed from the capillary nozzle by generating an electric field at the nozzle to ionise the said analyte and produce a beam of charged spray particles, and the beam of charged particles is injected into the ion trap through the inlet aperture. The pressure within the capillary is such that flow of the liquid through the capillary occurs only in the presence of the said electric field, and flow of ions into the ion trap is controlled by varying the electric field.
Claims19
A method of analyzing an analyte present in a liquid using a mass spectrometer incorporating an ion trap, the method comprising:
- providing a capillary with an outlet adjacent an inlet aperture for the mass spectrometer;
- electrospraying the liquid from the capillary outlet by generating an electric field at the outlet to produce a beam of charged spray particles;
- and
- injecting the beam of charged particles into the mass spectrometer through the inlet aperture, wherein the pressure within the capillary is such that flow of the liquid through the capillary outlet occurs only in the presence of said electric field, and wherein flow of charged particles into the mass spectrometer is controlled by varying the said electric field.
Dependencies are inferred from the claim text.