Conjugated 4'-desmethyl nucleoside analog compounds

The compound having the structure:

• ##STR14## wherein:
• L is a group of formula:
• R.sub.7 --[W].sub.a --[S--(CH.sub.2).sub.q ].sub.u --[HN--(CH.sub.2).sub.n ].sub.t --.sub.[O--(CH.sub.2).sub.m ].sub.v --Z--
• wherein:
• t, u and v are each independently integers from 0 to 200;
• m, n and q are each independently integers from 1 to 4;
• Z is S, O or HN;
• R.sub.7 is R.sub.c, H, or a protecting group;
• B.sub.x is a nucleobase;
• X is H, OH, O-alkyl, O-alkoxylalkyl, O-alkylamino, or F;
• Q is O;
• W is the residue of a linking moiety, said linking moiety being selected from the group consisting of acid chlorides, anhydrides, cyclic anhydrides, alkyl halides, organometallics, chloroformates, isocynates, hydrazines, acids, hydroxylamines, semicarbazides, thiosemicarbazides, hydrazones, hydrazides, trityl thiol, oximes, hydrazide-hydrazones, semicarbazones and semithiocarbazones;
• a is 0 or 1;
• R.sub.D is H, hydroxyl, an activated phosphorous group, a nucleoside, an activated nucleotide, a nucleotide, an oligonucleotide, an oligonucleoside or a protected derivative thereof;
• R.sub.C is alkyl, alkenyl, alkynyl, a polyamine, a polyether, a polythioether, a steroid molecule, a reporter molecule, an aromatic lipophilic molecule, a non-aromatic lipophilic molecule, a reporter enzyme, a peptide, a protein, a water soluble vitamin, a lipid soluble vitamin, a carbohydrate, a terpene molecule, a phospholipid, an intercalator, a cell receptor binding molecule, a crosslinking agent, or a porphyrin;
• and
• provided that t, u and v are not all simultaneously 0.

The compound having the structure:

• ##STR15## wherein:
• R.sub.C is O-alkyl, O-alkenyl, O-alkynyl, a polyamine, a polyether, a steroid molecule, a reporter molecule, an aromatic lipophilic molecule, a non-aromatic lipophilic molecule, a reporter enzyme, a peptide, a protein, a water soluble vitamin, a lipid soluble vitamin, a carbohydrate, a terpene molecule, a phospholipid, an intercalator, a cell receptor binding molecule, a crosslinking agent, or a porphyrin;
• B.sub.x is a nucleobase;
• X is H, OH, O-alkyl, O-alkoxyalkyl, O-alkylamino, or F;
• Q is O, S, CH.sub.2, CHF or CF.sub.2 ;
• and
• R.sub.D is H, hydroxyl, an activated phosphorous group, a nucleoside, an activated nucleotide, a nucleotide, an oligonucleotide, an oligonucleoside or a protected protected derivative thereof.

The compound having the structure:

• ##STR16## wherein:
• J is a leaving group;
• B.sub.x is a nucleobase;
• X is H, OH, O-alkyl, O-alkoxylalkyl, O-alkylamino, or F;
• Q is O, S, CH.sub.2, CHF or CF.sub.2 ;
• and
• R.sub.D is H, hydroxyl, an activated phosphorous group, a nucleoside, an activated nucleotide, a nucleotide, an oligonucleotide, an oligonucleoside or a protected derivative thereof.