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US 5,607,677 AGranted
Glucan drug delivery system and adjuvant
AssigneeAlpha-Beta Technology, Inc.
InventorsSpiros Jamas, Gary R. Ostroff, D. Davidson Easson, Jr.
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Abstract
The invention describes a whole .beta.-glucan drug delivery vehicle that non-specifically enhances the immune response, and is safe for human use. A drug is incorporated into a whole .beta.-glucan microparticle, and the combination is administered to an individual. The .beta.-glucan vehicle allows sustained release of the drug component while simultaneously enhancing the effectiveness of the drug by boosting the individual's endogenous immune response.
Claims1
A two-phase drug composition for use to stimulate an immune response in a mammal, comprising:
- a. a first phase comprising bioerodible whole .beta.-particles which are hollow spheres comprised of a semi-permeable glucan matrix;
- and
- b. a second phase comprising an immune stimulating drug which is capable of being incorporated within each of the whole glucan particles by natural diffusion;
- to form a two-phase drug composition the drug being contained within or dispersed in said whole .beta.-glucan particles, and the composition being capable, when placed in a physiological environment, of releasing the drug over time into the physiological environment, the whole .beta.-glucan particles being bioerodible in response to the physiological environment which whole .beta.-glucan particles stimulate an immune response in the mammal.
1 more element
Dependencies are inferred from the claim text.