Medical use, a medical method and a pharmaceutical preparation
OwnerPekka U. Heinoinventor
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Abstract
The invention concerns medical use, a medical method and a pharmaceutical preparation. The invention allows the action of .beta.-lactam antibiotics to be targeted and their side effects to be reduced by inactivation of part of the antibiotic in a desired section of the digestive tract distal to the stomach by administering, separately from or simultaneously with antibiotic, and enzyme, such as .beta.-lactamase, which breaks down said antibiotic.
Claims21
An oral pharmaceutical preparation with a programmed delivery pattern comprising a substantially pure .beta.-lactam antibiotic-degrading compound.
An oral pharmaceutical preparation with a programmed delivery pattern consisting essentially of a .beta.-lactam antibiotic degrading compound selected from a group consisting of .beta.-lactamase, an amidase and an active fragment of .beta.-lactamase or amidase.
A method of using a .beta.-lactam antibiotic degrading compound or an active fragment thereof comprising preparing a pharmaceutical preparation, suitable for oral administration, which comprises at least a .beta.-lactam antibiotic-degrading compound, such that by administering the preparation to a patient in need thereof the .beta.-lactam antibiotic-degrading compound breaks down antibiotics containing a .beta.-lactam ring into inactive or low-active forms in the esophagus, stomach, duodenum, small and large intestine of the digestive tract, thereby limiting the effect of the .beta.-lactam antibiotic and reducing the adverse effects of these antibiotics.
A method for reducing the adverse effects of antibiotic therapy with a .beta.-lactam antibiotic in the digestive tract comprising:
- a) administering an effective amount of a .beta.-lactam antibiotic-degrading compound which is liberated from a composition in the digestive tract;
- b) administering an effective amount of .beta.-lactam antibiotic which comes in contact with the .beta.-lactam antibiotic degrading compound in the digestive tract;
- said antibiotic breaking down into an inactive or a low-active product.
Dependencies are inferred from the claim text.