Amine polymer sequestrant and method of cholesterol depletion
AssigneeGelTex Pharmaceuticals, Inc.
InventorsW. Harry Mandeville, III, Stephen R. Holmes-Farley
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Abstract
An amine polymer includes first and second substituents bound to amines of the polymer. The first substituent includes a hydrophobic moiety. The second substituent includes a quaternary amine-containing moiety. A method for binding bile salts of bile acids in a mammal includes orally administering to the mammal a therapeutically-effective amount of the amine polymer.
Claims25
A method for binding bile salts in a mammal, comprising the step of orally administering to the mammal a therapeutic amount of an amine polymer having a first substituent, bound to a first amine of the amine polymer, that includes a hydrophobic aliphatic moiety, and a second substituent, bound to a second amine of the amine polymer, that includes an aliphatic quaternary amine-containing moiety.
A method for reducing blood cholesterol in a mammal, comprising the step of orally administering to the mammal a therapeutic amount of an amine polymer having a first substituent, bound to a first amine of the amine polymer, that includes a hydrophobic aliphatic moiety, and a second substituent, bound to a second amine of the amine polymer, that includes an aliphatic quaternary amine-containing moiety.
A method for treating atherosclerosis in a mammal, comprising the step of orally administering to the mammal a therapeutic amount of an amine polymer having a first substituent, bound to a first amine of the amine polymer, that includes a hydrophobic aliphatic moiety, and a second substituent, bound to a second amine of the amine polymer that includes an aliphatic quaternary amine-containing moiety.
A method for treating hypercholesterolemia in a mammal, comprising the step of orally administering to the mammal a therapeutic amount of an amine polymer having a first substituent, bound to a first amine of the amine polymer, that includes a hydrophobic aliphatic moiety, and a second substituent, bound to a second amine of the amine polymer, that includes an aliphatic quaternary amine-containing moiety.
A method of reducing cholesterol in a mammal comprising the step of orally administering to the mammal a therapeutic amount of a crosslinked poly(allylamine) polymer comprising:
- a) a first substituent, bound to an amine of the amine polymer, that includes a hydrophobic decyl moiety;
- and
- b) a second substituent, bound to an amine of the amine polymer that includes hexyltrimethylammonium, wherein the poly(allylamine) is crosslinked by epichlorohydrin, prior to substitution by (a) and (b), and said epichlorohydrin is present in a range of between about 0.5 and twenty mole percent of the amines of the poly(allylamine).
Dependencies are inferred from the claim text.