US 5,604,231 AGranted

Pharmaceutical compositions for prevention and treatment of ulcerative colitis

OwnerCarr J. Smith, Patrick M. Lippiello +3inventors

InventorsCarr J. Smith, Patrick M. Lippiello, Merouane Bencherif, William S. Caldwell, Gary M. Dull

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Abstract

Patients suffering from or susceptible to an idiopathic chronic inflammatory bowel disease (e.g., ulcerative colitis) are treated with pharmaceutical compositions. Those patients are treated by administration of an effective amount of aryl substituted aliphatic compound, an aryl substituted olefinic amine compound or an aryl substituted acetylenic compound. Exemplary compounds are (E)-4-(5-pyrimidinyl)-3-butene-1-amine, (E)-4-[3-(5-methoxypyridin)yl]-3-butene-1-amine, (E)-N-methyl-4-(5-pyrimidinyl)-3-butene-1-amine, (E)-N-methyl-4-[3-(5-methoxypyridin)yl]-3-butene-1-amine, (E)-metanicotine, (Z)-metanicotine, N-methyl-(3-pyridinyl)-butane-1-amine, N-methyl-4-(3-pyridinyl)-3-butyne-1-amine and (E)-N-methyl-4 -[3-(6-methylpyrindin)yl]-3-butone-1-amine.

Claims21

Dependent claims

A method for providing prevention or treatment of an inflammatory bowel disease, the method comprising administering to a subject an effective amount of a compound having the formula:

##STR3## where X is nitrogen or carbon bonded to a substituent species characterized as having a sigma m value between about -0.3 and about 0.75;
n is an integer which ranges from 1 to 5;
Z' and Z" individually represent hydrogen or alkyl containing one to five carbon atoms;
A, A' and A" individually represent hydrogen, alkyl containing one to seven carbon atoms, or halo;
the dashed line in the structure represents a C--C single bond, a C--C double bond or a C--C triple bond;
the wavy line in the structure represents a cis (Z) or trans (E) form of the compound when the dashed line is a C--C double bond;
and X' represents CH.sub.2 when the dashed line is a C--C single bond, CH when the dashed line is a C--C double bond, and C when the dashed line is a C--C triple bond.

4 more elements

Dependencies are inferred from the claim text.

Facts

Application: 08/364,980Filed 6 Jan 1995
Granted: 18 Feb 1997
Term ends: Not estimatedThe source records don’t support an estimate.

Classification8 codes

A61K 31/44
Having six-membered rings with one nitrogen as the only ring hetero atom: non condensed pyridines; Hydrogenated derivatives thereof
A61K 31/4406
Non condensed pyridines; Hydrogenated derivatives thereof: only substituted in position 3, e.g. zimeldine
A61K 31/505
Having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines: pyrimidines; Hydrogenated…
A61P 1/00
Drugs for disorders of the alimentary tract or the digestive system