Fatty acid derivatives
AssigneeScotia Holdings PLC
InventorsDavid F. Horrobin, Philip Knowles
Life of this patent
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Abstract
An NSAID in the form of a compound with an essential fatty acid or essential fatty acid alcohol, particularly an NSAID as listed in categories 1 to 9 herein. Further, a method of preparation of a medicament for the treatment including prophylatic treatment of rheumatoid arthritis, osteoarthritis and related disorders; dysmenorrhoea; dementias, including Alzheimer's disease; or any other inflammatory or other conditions specified herein, wherein the said NSAID is used.
Claims15
An NSAID in the form of a compound in which the NSAID is chemically linked to an n-6 or n-3 essential fatty acid selected from the group consisting of linolenic acid, gamma-linolenic acid, dihomo-gamma-linolenic acid, arachidonic acid, adrenic acid, docosapentaenoic n-6 acid, alpha-linolenic acid, stearidonic acid, the 20:4n-3 acid, eicosapentaenoic acid, docosapentaenoic n-3 acid, docosahexaenoic acid, and the corresponding fatty alcohols, wherein said NSAID is selected from the group consisting of a salicylate, a pyrazolone, a para-aminophenol, indomethacin, sulindac, a fenamate, a propionic acid, an oxicam, a phenylacetic acid, tolmetin, etodolac and nabumetone.
A composition comprising an NSAID selected from the group consisting of a salicylate, a pyrazole, a para-aminophenol, indomethacin, sulindac, a fenamate, a propionic acid, an oxicam, a phenylacetic acid, tolmetin, etodolac and nabumetone in the form of a compound in which the NSAID is chemically linked to an n-6 or n-3 essential fatty acid selected from the group consisting of linolenic acid, gamma-linolenic acid, dihomo-gamma-linolenic acid, arachidonic acid, adrenic acid, docosapentaenoic n-6 acid, alpha-linolenic acid, stearidonic acid, eicosapentaenoic acid, docosapentaenoic n-3 acid, docosahexaenoic acid, and the corresponding fatty alcohols, together with a free essential fatty acid or an essential fatty acid glyceride or phospholipid, as a carrier.
A method of treating rheumatoid arthritic, osteoarthritic, dysmenorrhea or dementia comprising administering to a person in need of such treatment comprising an NSAID in the form of a compound in which the NSAID is chemically linked to n-6 or n-3 essential fatty acid selected from the group consisting of linoleic acid, gamma-linolenic acid, dihomo-gamma-linolenic acid, arachidonic acid, adrenic acid, docosapentaenoic n-6 acid, alpha-linolenic acid, stearidonic acid, eicosapentaenoic acid, docosapentaenoic n-3 acid, docosahexaenoic acid, and the corresponding fatty alcohols, wherein said NSAID is selected from the group consisting of a salicylate, a pyrazolone, a para-aminophenol, indomethacin, sulindac, a fenamate, a priopionic acid, an oxicam, a phenylacetic acid, tolmetin, etodolac and nabumetone.
A method of treating rheumatoid arthritis, osteoarthritis, dysmenorrhea or dementia comprising administering to a person in need of such treatment a composition comprising together with a carrier, an NSAID in the form of a compound in which the NSAID is chemically linked to an n-6 or n-3 essential fatty acid selected from the group consisting of linoleic acid, gamma-linolenic acid, dihomo-gamma-linolenic acid, arachidonic acid, adrenic acid, docosapentaenoic n-6 acid, alpha-linolenic acid, stearidonic acid, eicosapentaenoic acid, docosapentaenoic n-3 acid, docosahexaenoic acid, and the corresponding fatty alcohols, wherein said NSAID is selected from the group consisting of salicylate, a pyrazolone, a para-aminophenol, indomethacin, sulindac, a fenamate, a propionic acid, an oxicam, a phenylacetic acid, tolmetin, etodolac and nabumetone in the form of a compound with an n-6 or n-3 essential fatty acid or essential fatty alcohol comprising a salicylate, a pyrazolone, a paraaminophenol, indomethacin, sulindac, a fenamate, a proprionic acid, an oxicam, a phenylacetic acid, tolmetin, etodolac and nabumetone.
A method according to claim 24, wherein the NSAID is linked to gamma-linolenic, dihomo-gamma-linolenic acid or eicosapentaenoic acid, or the corresponding fatty alcohols.
Dependencies are inferred from the claim text.