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US 5,602,301 AGranted
Non-human mammal having a graft and methods of delivering protein to myocardial tissue
AssigneeIndiana University Foundation
InventorLoren J. Field
Life of this patent
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Abstract
Described are preferred myocardial grafts of skeletal myoblasts or cardiomyocytes, and cellular compositions and methods useful in obtaining the grafts. The myocardial grafts are stable and can be used, for example, to deliver recombinant proteins directly to the heart.
Claims13
A non-human mammal which has a myocardial graft, the mammal comprising:
- viable skeletal myoblasts or cardiomyocytes having a detectable marker directly introduced into the myocardial tissue of the mammal.
A method for forming a stable myocardial graft in a mammal, the method comprising:
- directly introducing viable skeletal myoblasts or cardiomyocytes into the myocardial tissue of the mammal such that the injected skeletal myoblasts or cardiomyocytes for a stable myocardial graft in the mammal.
A method for delivering proteins to the myocardial tissue of a mammal, the method comprising:
- directly introducing viable skeletal myoblasts or cardiomyocytes expressing a DNA sequence encoding a protein into the myocardial tissue of the mammal such that the injected skeletal myoblasts or cardiomyocytes form a stable graft, wherein the DNA sequence is expressed sufficiently for delivery of the protein to the myocardial tissue.
Dependencies are inferred from the claim text.