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OwnerLaszlo K. Csataryinventor
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A process for preparing a purified virus vaccine comprises the steps of purifying a fluid containing a virus by centrifugation, ultracentrifuging to pellet the supernatant, purifying the virus by sucrose gradient ultracentrifugation, rehydration and lyophilization. Desirably, a modified starch, such as hydroxyethyl starch having a molecular weight in the range 100,000-300,000, is added as a protective colloid prior to lyophilization. The virus is selected from the group consisting of avian paramyxovirus, avian herpesvirus, avian rotavirus, avian bronchitis, avian encephalitis, avian bursiris (Gumboro) virus, Marek's disease virus, parvovirus, Newcastle disease virus, human paramyxovirus, human parvovirus, human adenovirus, and mixtures thereof. A purified virus vaccine made by the foregoing method is useful for the treatment and control of mammalian disease of viral origin.
A highly purified stable vaccine suitable for administration to humans produced from a live, stabilized virus apathogenic to humans comprising arian bursitis virus or Newcastle disease virus stabilized with an effective amount of a protective colloid comprising a modified starch.
A method for producing a stable vaccine with a purity suitable for human administration from a selected virus apathogenic to humans or a selected virus pathogenic to humans, comprising:
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