Amino acid-derived diaminopropanols
AssigneePharm-Eco Laboratories, Inc.
InventorsBiman Pal, Siya Ram, Yesh P. Sachdeva, Jaechul Shim, Salah A. Zahr, Emile Al-Farhan, Richard L. Gabriel
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Abstract
The present invention relates to a method of forming a 1,3-diamino-3-substituted-2-propanol chemical intermediate from which various chemicals, such as selected protease-inhibitors and other drugs, as well as polymers, can be synthesized. The method includes contacting a nitromethyl amino acid compound with at least one reducing agent to form the 1,3-diamino-3-substituted-2-propanol chemical intermediate.
Claims3
A composition predominently comprising a 2S diastereomer of a compound represented by the formula ##STR18## and salts thereof wherein:
- R.sup.1 is a protecting group;
- R.sup.2 is selected from the group consisting of --H, C1-C18 alkyl, aryl, heteroaryl, acetyl and tosyl;
- R.sup.3 is a side-chain of an amino acid;
- and
- R.sup.4 and R.sup.5 are each independently selected from the group consisting of --H, alkyl, aryl, nitrile and alkoxycarbonyl.
A compound wherein the compound is 2R, 33-3-amino-3-benzyl-1-nitro-2-propanol.
Dependencies are inferred from the claim text.