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US 5,599,852 AGranted
Injectable microdispersions for soft tissue repair and augmentation
AssigneeEthicon, Inc.
InventorsAngelo G. Scopelianos, Steven C. Arnold, Rao S. Bezwada, Mark B. Roller, Shawn T. Huxel
Life of this patent
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Abstract
The present invention provides injectable, bioabsorbable microdispersions suitable for use as a soft tissue repair or augmentation material in animals comprising a fluid carrier that is a liquid polymer selected from the group consisting of liquid polymers and a particulate material. Additionally, the present invention also discloses methods of using these microdispersions for tissue augmentation and repair as well as kits which include prefilled containers to facilitate the use of these materials.
Claims25
A fluid, injectable, bioabsorbable microdispersion suitable for use as a soft tissue repair or augmentation material in animals comprising
- a fluid carrier that is a liquid polymer selected from the group consisting of liquid polymers of a plurality of at least two different first lactone repeating units and liquid polymers of a plurality of first lactone and second lactone repeating units;
- wherein the first lactone repeating units are selected from the group consisting of .epsilon.-caprolactone repeating units, trimethylene carbonate repeating units, ether lactone repeating units and combinations thereof and the second lactone repeating units are selected from the group consisting of glycolide repeating units, lactide repeating units, p-dioxanone repeating units and combinations thereof;
- and
- a particulate material that is selected from the group consisting of solid homopolymers of poly(.epsilon.-caprolactone), solid homopolymers of poly(p-dioxanone), solid homopolymers of poly(trimethylene carbonate), solid copolymers of a plurality of .epsilon.-caprolactone repeating units and third lactone repeating units, solid copolymers of a plurality of trimethylene carbonate repeating units and second lactone repeating units;
- wherein the third lactone repeating units are selected from the group consisting of glycolide repeating units, lactide repeating units, trimethylene carbonate repeating units, p-dioxanone repeating units, 1,4-dioxepan-2-one repeating units, 1-5-dioxepan-2-one repeating units and combinations thereof.
2 more elements
A preloaded pharmaceutical container having a fluid, injectable, bioabsorbable microdispersion loaded therein, comprising:
- a microdispersion of a fluid carrier that is a liquid polymer selected from the group consisting of liquid polymers a plurality of at least two different first lactone repeating units and liquid polymers of a plurality of first lactone and second lactone repeating units;
- wherein the first lactone repeating units are selected from the group consisting of .epsilon.-caprolactone repeating units, trimethylene carbonate repeating units, ether lactone repeating units and combinations thereof and the second lactone repeating units are selected from the group consisting of glycolide repeating units, lactide repeating units, p-dioxanone repeating units and combinations thereof;
- and
- a particulate material that is selected from the group consisting of solid homopolymers of poly(.epsilon.-caprolactone), solid homopolymers of poly(p-dioxanone), solid homopolymers of poly(trimethylene carbonate), solid copolymers of a plurality of .epsilon.-caprolactone repeating units and third lactone repeating units, solid copolymers of a plurality of trimethylene carbonate repeating units and second lactone repeating units;
- wherein the third lactone repeating units are selected from the group consisting of glycolide repeating units, lactide repeating units, trimethylene carbonate repeating units, p-dioxanone repeating units, 1,4-dioxepan-2one repeating units, 1-5-dioxepan-2-one repeating units and combinations thereof;
- and
- a container for storing said microdispersion, said container having a cylindrical storage area and an outlet and an end to said cylindrical storage area, the outlet having a removable sterile seal, the end having a movable sterile seal which may be advanced into said cylindrical storage area.
4 more elements
A pharmaceutical kit suitable for administering a fluid, injectable, bioabsorbable microdispersion suitable for use as a soft tissue repair or augmentation material comprising:
- a microdispersion of a fluid carrier that is a liquid polymer selected from the group consisting of liquid polymers of a plurality at least two different first lactone repeating units and liquid polymers of a plurality of first lactone and second lactone repeating units;
- wherein the first lactone repeating units are selected from the group consisting of .epsilon.-caprolactone repeating units, trimethylene carbonate repeating units, ether lactone repeating units and combinations thereof and the second lactone repeating units are selected from the group consisting of glycolide repeating units, lactide repeating units, p-dioxanone repeating units and combinations thereof;
- and
- a particulate material that is selected from the group consisting of solid homopolymers of poly(.epsilon.-caprolactone), solid homopolymers of poly(p-dioxanone), solid homopolymers of poly(trimethylene carbonate), solid copolymers of a plurality of .epsilon.-caprolactone repeating units and third lactone repeating units, solid cOpolymers of a plurality of trimethylene carbonate repeating units and second lactone repeating units;
- wherein the third lactone repeating units are selected from the group consisting of glycolide repeating units, lactide repeating units, trimethylene carbonate repeating units, p-dioxanone repeating units, 1,4-dioxepan-2-one repeating units, 1-5-dioxepan-2-one repeating units and combinations thereof;
- and
- a device containing said microdispersion, said device having an outlet for said microdispersion, an ejector for expelling the microdispersion through the outlet and a hollow tubular member fitted to the outlet for administering the microdispersion into a site within. a body.
4 more elements
Dependencies are inferred from the claim text.