Method for reducing absorption of undesired lipids in the gastrointestinal tract
OwnerAllan S. Hoffman, N. S. Choiinventors
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Abstract
A composition is disclosed for use in reducing the availability of undesired lipids, such as cholesterol, in the fluid media of the gastrointestinal tract prior to absorption of the lipids across the cells lining the tract. The composition is a nontoxic, substantially nondigestible polymer to which ligands are chemically bonded through biologically stable ether groups. The ligands scavenge the undesired lipids from the fluid media.
Claims4
A method for effecting reduction of the biologically active level of an undesired lipid present in the fluid media of the gastrointestinal tract of humans or animals, said undesired lipid capable of being bound by cholesterol, comprising:
- orally administering therapeutically effective doses of a pharmaceutical composition containing a substantially water-soluble nondigestible polymer having multiple reactable hydroxyl groups, wherein said polymer is selected from the group consisting of cellulose polymers, algin, pectin, agar, chitin, polyvinyl alcohol and hydroxyethyl methacrylate, bonded through a biologically stable ether linkage to cholesterol, the cholesterol being capable of attracting and bonding, by means of van der Waals or hydrophobic forces, the undesired lipid present in the gastrointestinal tract for a time sufficient for the composition to be discharged from the gastrointestinal tract, and wherein the polymer is bonded to cholesterol by reacting cholesterol with the polymer at a ratio of 1-50% by weight cholesterol relative to the polymer.
Dependencies are inferred from the claim text.